Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) However, if handling bulk powders, observance of appropriate safeguards is recommended. No. 2008-2023 ChemPoint. SDS. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Chemical Formula: (C6H10O5)n 1.4. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. endobj Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine 3 0 obj The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Product Name: Microcrystalline Cellulose 1.2. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. By producing Avicel . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Battista, O. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Cellulose microcrystalline for column chromatography. . In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. B;vLZpHU%ChUyD+[ AVICEL RC 581. };khd5x=fr 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. PDF (28.38 mb) 2022 Corporate Fact Sheet. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. <> Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. If you are already a ChemPoint customer then sign up for access to our online ordering website. It is a white, free-flowing powder. 130. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. CAS #: 9004-34-6 1.6. Superior Performance: Provides excellent water uptake and rapid swelling . At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Unique functionality for a broad range of pharmaceutical applications. Go to Investor Relations. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Revision No. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Hi, let us know if you have any questions as you visit our website. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge It is also inert and biocompatible. Manufactured by: China . Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Quantity: 1 700 kgs. Microcrystalline Cellulose; Cellulose; Functions. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. << Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Avicel RC-591 & CL-611 - Description. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. . It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Magazine: Material safety data sheet - FMC Corporation. Request media, explore upcoming events and read our latest updates. 0.25 - 0.37. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. We respect your privacy FMC Privacy Policy. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. High performance lubricant that brings more to the tablet. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? : CL-611NF Date Approved: 01/13/2010. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. It is also used in plaque assays for counting. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. No. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. /Contents 4 0 R <> 8 0 obj CoA. All rights reserved. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. Test Data Available. Are you looking for information about products and services by region? : 160182. endstream %PDF-1.4 POLYOX resins are nonionic polyethylene oxide solubility polymers. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. (Microcrystalline Cellulose Market Pr. BIOACCUMULATIVE POTENTIAL We know that our customers need to provide reliable and consistent products to their patients. Meet our leadership team. 1 0 obj 102331. MSDS Ref. >> The typical mean particle size is 20200 m. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Trademarks: Avicel PH-102. endobj (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. An agricultural sciences company. Some substance identifiers may have been claimed confidential, or may . Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. 1 0 obj We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. stream cas:9000-11-7 msds Carboxymethyl cellulose. FMC Corporation. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. 4. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. No. Remove Packaging: 34 x 50 kgs fiber drums. (&E. <> By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. q86@on$^X_HuH;3` (1962). There may be more fiber in your food than you realized. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. 6 It works as a moisture sponge and permits the controlled growth of spheroids. These grades have particle sizes ranging from <30 to approximately 200. Well-recognized product that can do it all. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . gwf;J(e0o|1p{R~P^);ao!%{0KD7. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Biologicals by FMC. . A., and Smith, P. A. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Report Category. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. JFIF ` ` ZExif MM * J Q Q Q C FMC, JRS and Mingtai were estimated to hold for . JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. % pH 6.0 to 8.0 . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . 5 0 obj << xv}O2' H~KEe9>G/,:9\i Powder becomes slippery when wet. Aqueous suspensions of microcrystalline cellulose have . : 1. . 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. No. All Rights Reserved. Date Approved: 05/25/2010. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Chemical Formula: (C6H10O5)n 1.4. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication These, in turn, are assembled into fibrils in the cell wall. /Parent 3 0 R GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. %PDF-1.5 Document(s): certificate data msds. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. ( Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. /MediaBox [0 0 612 792] Medium size standard MCC grade, suited for the majority of directly compressible actives. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. common form is used in vitamin supplements or tablets. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Micro Crystalline Cellulose. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. CAS 9004-34-6, pH 5 - 7.5. endobj Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . Heavy metals, % NMT 0.001 Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. MATERIAL SAFETY DATA SHEET. Molecular Weight null. Van Veen, G.K. Bolhuis, Y.S. % Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Cellulose microcrystalline. Avicel PC 611 Microcrystalline Cellulose. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no However, consumption of large quantities of the material may have a laxative effect. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. PDF (4.11 mb) Footer menu 1. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. 1 0 obj % Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. It is available in different grades and particle sizes. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. A family of polysaccharide products that allow distinctive drug delivery solutions. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. G2W4de=u183KGH{ vQ#4:1\wc X\o^ Truly distinctive drug delivery solutions. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc.